Download E-books Sialo-Xenoantigenic Glycobiology: Molecular Glycobiology of Sialylglycan-Xenoantigenic Determinants in Pig to Human Xenotransplantation (Sungkyunkwan University Outstanding Research) PDF

By Cheorl-Ho Kim

Carbohydrate antigens on glycoconjugates of mammalian cells play an important roles in numerous organic strategies and are epitopes famous by way of the immune process, as glycobiology has highly been advanced in the past 20 years. The booklet makes a speciality of sialic acid–based xenoantigenes. In pig to human xenotransplantation, publicity of pig organs to human blood leads to hyper acute rejection (HAR), as a result of ameliorations in carbohydrate epitopes among human and pig vascular endothelia. even if Gal-antigen as significant antigen used to be eradicated, the rest non-Gal antigens are thought of to be xenoantigens. Sialosyl-Tn or Hanganutziu-Deicher (HD), are non-Gal antigens particular to traditional antibodies in human. to beat rejection responses similar to HAR, stories of genes desirous about carbohydrate antigens, inflicting xenoantigenicity, are worthwhile. wisdom of pig glycosyltransferases also are priceless to use to xenoantigen overlaying or identity of the xenoantigenic sialylglycan(s). within the first bankruptcy the screening for pig glycosyltransferase genes for xenoantigens is gifted. within the bankruptcy II to IV the cloning, characterization, and research of the regulatory mechanism of the pig CMAH gene in NeuGc biosynthesis is proven. finally, the results of an alteration of pig glycosylation styles on human serum-mediated cytotoxicity, because of human sialyltransferases together with hST6GalNAc IV is presented.

 

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